HCID 67366001, compound → HCID 87452393, compound

HRID 2064541Notes

Reaction equation

HRID 2064541 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:32][C:33]1[CH:34]=[C:35]([CH:39]=[CH:40][CH:41]=1)[C:36]([OH:38])=[O:37])[S:9]([C:12]1[CH:17]=[C:16]([C:18]([NH:20][N:21]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:23][CH:22]2[CH3:30])=[O:19])[CH:15]=[CH:14][C:13]=1[Cl:31])(=[O:11])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[CH2:43][O:44]/[N:45]=[N+:46](/[N:48]([CH2:51][CH3:52])[CH2:49][CH3:50])\[O-:47]>>[C:1]([O:5][C:6]([N:8]([CH2:32][C:33]1[CH:34]=[C:35]([CH:39]=[CH:40][CH:41]=1)[C:36]([O:38][CH2:43][O:44]/[N:45]=[N+:46](\[O-:47])/[N:48]([CH2:51][CH3:52])[CH2:49][CH3:50])=[O:37])[S:9]([C:12]1[CH:17]=[C:16]([C:18]([NH:20][N:21]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:23][CH:22]2[CH3:30])=[O:19])[CH:15]=[CH:14][C:13]=1[Cl:31])(=[O:10])=[O:11])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 67366001HCID 67366001, compoundHCID 87377294HCID 87377294, compound

Product 1

HCID 87452393HCID 87452393, compound

Procedure

The product obtained in Step C of Example 1 is reacted with N—[(Z)-(chloromethoxy)-NNO-azoxy]-N-ethylethanamine in accordance with the process conditions described in Step D of Example 1. The title product is obtained in the form of a yellow solid after chromatography on a silica column using as eluant a 65/35 n-heptane/ethyl acetate mixture.

Sources & evidence

ORD record
ord-22978afc9007460c82c997bbeaefb661
Source dataset
uspto-grants-2012_10
Patent number
US08288433B2

Reaction notes

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