4-Aminobenzoic Acid → HCID 59320711, compound

HRID 2064557Notes

Reaction equation

HRID 2064557 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][C:5](=O)[CH:4]([CH2:9][C:10](=O)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH2:3]1.[NH2:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1>>[CH3:1][CH:2]1[CH2:7][CH2:6][C:5]2[N:18]([C:19]3[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=3)[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)=[CH:9][C:4]=2[CH2:3]1

Participants

3

Reactant 2

HCID 9784-Aminobenzoic AcidHCID 68595142HCID 68595142, compound

Product 1

HCID 59320711HCID 59320711, compoundYield 65%

Procedure

Following the general methods as outlined under Intermediate 13, starting from 4-methyl-2-(2-oxo-2-pyridin-2-ylethyl)cyclohexanone and 4-aminobenzoic acid, the title compound was isolated in 65% yield (96% purity by HPLC). MS(ESI+): 333.5; MS(ESI−): 331.6.

Sources & evidence

ORD record
ord-5ffe59414b3c427d8ea8fdc7934f027c
Source dataset
uspto-grants-2012_10
Patent number
US08288432B2

Reaction notes

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