HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-amino-1,3-thiazole-4-carboxylate → 2-(5-methyl-2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)-1,3-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-amino-1,3-thiazole-4-carboxylate | HCID 840099 | — |
| Reactant | 4-Methyl-2-(2-oxo-2-phenylethyl)cyclohexanone | HCID 12270340 | — |
| Product | 2-(5-methyl-2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)-1,3-thiazole-4-carboxylic acid | HCID 59214638 | 49% |
Reaction Steps
Following the general methods as outlined under Intermediate 13, starting from 4-methyl-2-(2-oxo-2-phenylethyl)cyclohexanone and methyl 2-amino-1,3-thiazole-4-carboxylate, the title compound was isolated in 49% yield (93% purity by HPLC). MS(ESI+): 339.5; MS(ESI−): 337.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288432B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-682deb42fa5a418a8fc5e4aa83b7b0d1 |
| Source note | uspto-grants-2012_10 |