HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminopyridine-2-carboxylic acid → 5-(5-methyl-2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)pyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminopyridine-2-carboxylic acid | HCID 4179726 | — |
| Reactant | 4-Methyl-2-(2-oxo-2-phenylethyl)cyclohexanone | HCID 12270340 | — |
| Product | 5-(5-methyl-2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)pyridine-2-carboxylic acid | HCID 59320720 | 71% |
Reaction Steps
Following the general methods as outlined under Intermediate 13, starting from 4-methyl-2-(2-oxo-2-phenylethyl)cyclohexanone and 5-aminopyridine-2-carboxylic acid, the title compound was isolated in 71% yield (96% purity by HPLC). MS(ESI+): 334.7; MS(ESI−): 332.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288432B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-fb705cf87c784a5599c8ffae88dab5fb |
| Source note | uspto-grants-2012_10 |