4-Aminobenzoic Acid → HCID 59320717, compound

HRID 2064562Notes

Reaction equation

HRID 2064562 reaction equation
[CH3:1][CH:2]1[CH2:7][CH:6]([CH2:8][C:9]([C:11]2[CH:12]=[CH:13][C:14]3[O:19][CH2:18][C:17](=[O:20])[NH:16][C:15]=3[CH:21]=2)=O)[C:5](=O)[CH2:4][CH2:3]1.[NH2:23][C:24]1[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=1>>[CH3:1][CH:2]1[CH2:3][CH2:4][C:5]2[N:23]([C:24]3[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=3)[C:9]([C:11]3[CH:12]=[CH:13][C:14]4[O:19][CH2:18][C:17](=[O:20])[NH:16][C:15]=4[CH:21]=3)=[CH:8][C:6]=2[CH2:7]1

Participants

3

Reactant 2

HCID 9784-Aminobenzoic AcidHCID 68596159HCID 68596159, compound

Product 1

HCID 59320717HCID 59320717, compoundYield 60%

Procedure

Following the general methods as outlined under Intermediate 13, starting from 6-[(5-methyl-2-oxocyclohexyl)acetyl]-2H-1,4-benzoxazin-3(4H)-one and 4-aminobenzoic acid, the title compound was isolated in 60% yield (98% purity by HPLC). MS(ESI+): 403.7; MS(ESI−): 401.2.

Sources & evidence

ORD record
ord-e00b94cf148842d8b75b2548c54d7841
Source dataset
uspto-grants-2012_10
Patent number
US08288432B2

Reaction notes

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