4-Aminobenzoic Acid → HCID 59320713, compound

HRID 2064563Notes

Reaction equation

HRID 2064563 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][C:5](=O)[CH:4]([CH2:9][C:10](=O)[C:11]2[S:12][CH:13]=[CH:14][N:15]=2)[CH2:3]1.[NH2:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=1>>[CH3:1][CH:2]1[CH2:7][CH2:6][C:5]2[N:17]([C:18]3[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][CH:19]=3)[C:10]([C:11]3[S:12][CH:13]=[CH:14][N:15]=3)=[CH:9][C:4]=2[CH2:3]1

Participants

3

Reactant 2

HCID 9784-Aminobenzoic AcidHCID 59320719HCID 59320719, compound

Product 1

HCID 59320713HCID 59320713, compoundYield 45%

Procedure

Following the general methods as outlined under Intermediate 13, starting from 4-methyl-2-[2-oxo-2-(1,3-thiazol-2-yl)ethyl]cyclohexanone and 4-aminobenzoic acid, the title compound was isolated in 45% yield (94% purity by HPLC). MS(ESI+): 339.5; MS(ESI−): 337.7.

Sources & evidence

ORD record
ord-b7cee6c584ac4e88b926a40fe74154de
Source dataset
uspto-grants-2012_10
Patent number
US08288432B2

Reaction notes

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