HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Ethylpiperidin-1-yl)propan-1-amine → 4-(5-methyl-2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Ethylpiperidin-1-yl)propan-1-amine | HCID 4117479 | — |
| Reactant | 4-(2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)benzoic acid | HCID 6623370 | — |
| Product | 4-(5-methyl-2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)benzoic acid | HCID 20887555 | 62% |
Reaction Steps
Following the general methods as outlined under Example 1, starting from 4-(2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)benzoic acid (Intermediate 7) and 3-(2-ethylpiperidin-1-yl)propan-1-amine, the title compound (8) was isolated as a beige solid in 62% yield (94% purity by HPLC). MS(ESI+): 470.8; MS(ESI−): 468.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288432B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4995467ed6ca4472a3e41b1257ee8488 |
| Source note | uspto-grants-2012_10 |