HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,5-Dimethyl-1,2-phenylenediamine → HCID 135506541, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,5-Dimethyl-1,2-phenylenediamine | HCID 76635 | — |
| Reactant | Sodium Pyrosulfite | HCID 656671 | — |
| Reactant | 4-bromo-1H-pyrazole-5-carbaldehyde | HCID 2782154 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 135506541 | HCID 135506541 | — |
Reaction Steps
Starting with 100 mg of commercial 4-bromo-2H-pyrazole-3-carboxaldehyde, 77.8 mg of 4,5-dimethyl-1,2-phenylenediamine, and 108.6 mg of sodium metabisulphite, in 1 ml of ethanol and 2 ml of dimethylformamide, and after purification by SPE (SCX phase, washing with methanol, extraction with 2N ammoniacal methanol) followed by a chromatography under pressure on silica, 143.2 mg of 2-(4-bromo-2H-pyrazol-3-yl)-5,6-dimethyl-1H-benzimidazole are obtained in the form of a yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288425B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-2737ab3da3814fd5aec26b8a30414950 |
| Source note | uspto-grants-2012_10 |