Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 4-Chloro-5-methylbenzene-1,2-diamine | HCID 2801468 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 178422326 | HCID 178422326 | — |
Reaction Steps
A solution of 5-chloro-4-methyl-1,2-phenylenediamine (7.8 g) in a mixture of formic acid (35 mL) and hydrochloric acid (300 mL) was heated at 50° C. for 3 hours then treated with ammonium hydroxide solution until the solution was basic. The reaction mixture was then extracted with dichloromethane. The extracts were evaporated to give 6-chloro-5-methyl-1H-benzoimidazole (7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08288425B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-268aecd43ad9496d950dfeba1e7333ae |
|---|
| Source note | uspto-grants-2012_10 |
|---|
