HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2064642Generated: October 31, 2026
Diethyl Oxalate → Ethyl 2-oxo-2-(2-oxocyclohexyl)acetate
https://huagongshe.com/reaction/2064642
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | Cyclohexanone | HCID 7967 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-oxo-2-(2-oxocyclohexyl)acetate | HCID 219637 | — |
Reaction Steps
A solution of sodium (1.75 g) in ethanol (100 ml) was treated with a mixture of diethyl oxalate (9.41 ml) and cyclohexanone (7.18 ml). The mixture was heated to 60° C. for 5 hours then cooled and then evaporated to yield oxo-(2-oxo-cyclohexyl)-acetic acid ethyl ester as a brown foam (16.635 g). LC-MS (METHOD B): RT 3.10 minutes; 197 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08288425B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-23299135a5884d4386bb0b463a42a8fa |
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| Source note | uspto-grants-2012_10 |
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