HCID 178507994, compound → HCID 178506405, compound

HRID 2064678Notes

Reaction equation

HRID 2064678 reaction equation
[F:1][CH:2]([F:27])[O:3][C:4]1[CH:26]=[CH:25][C:7]2[NH:8][C:9](C3C([N+]([O-])=O)=CN(C4CCCCO4)N=3)=[N:10][C:6]=2[CH:5]=1.FC(F)OC1C=CC2NC([C:38]3[C:42]([NH2:43])=[CH:41][N:40]([CH:44]4[CH2:49][CH2:48][CH2:47][CH2:46][O:45]4)[N:39]=3)=NC=2C=1>>[F:27][CH:2]([F:1])[O:3][C:4]1[CH:26]=[CH:25][C:7]2[NH:8][C:9]([NH:43][C:42]3[CH:38]=[N:39][N:40]([CH:44]4[CH2:49][CH2:48][CH2:47][CH2:46][O:45]4)[CH:41]=3)=[N:10][C:6]=2[CH:5]=1

Participants

3

Reactant 2

HCID 178507994HCID 178507994, compoundHCID 178526769HCID 178526769, compound

Product 1

HCID 178506405HCID 178506405, compound

Procedure

By proceeding in a manner similar to Reference Example 49(a) above but using 5-difluoromethoxy-2-[4-nitro-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-1H-benzoimidazole [Reference Example 50(e)], there was prepared 3-(5-difluoromethoxy-1H-benzoimidazol-2-yl)-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-4-ylamine (730 mg) as a pale brown solid. LC-MS (METHOD N): RT=3.27 minutes, 350.29 (M+H)+.

Sources & evidence

ORD record
ord-1b9b847674eb4256a48cfeaaa65e112a
Source dataset
uspto-grants-2012_10
Patent number
US08288425B2

Reaction notes

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