HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dinitrophenol → 2-(3,4-Dinitro-phenoxy)-ethyl-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dinitrophenol | HCID 11348 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3,4-Dinitro-phenoxy)-ethyl-morpholine | HCID 22477691 | 79.2% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of 3,4-dinitrophenol (250 mg), 4-(2-chloroethyl)morpholine hydrochloride (252 mg) and potassium carbonate (375 mg) in dimethylformamide (3 ml) was heated at 120° C. for 20 minutes in a Personal Chemistry Smith Creator microwave. The reaction mixture was partitioned between ethyl acetate and water and the organic layer dried over magnesium sulfate, filtered and the filtrate concentrated in vacuo to give 4-[2-(3,4-dinitro-phenoxy)-ethyl]-morpholine (319 mg) as a yellow oil. LC-MS (METHOD B): RT=2.13 minutes, 298 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288425B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-22f8f98cdbe44dbf958a00c107061a5d |
| Source note | uspto-grants-2012_10 |