Cyclopropanecarbothioamide → 2-Cyclopropyl-5-(3-fluoro-4-methyl-phenyl)-thiazole-4-carboxylic Acid Methyl Ester

HRID 2064724Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:16])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([F:13])[CH:7]=1.[CH:17]1([C:20](=[S:22])[NH2:21])[CH2:19][CH2:18]1>>[CH3:1][O:2][C:3]([C:4]1[N:21]=[C:20]([CH:17]2[CH2:19][CH2:18]2)[S:22][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([F:13])[CH:7]=1)=[O:16]

Participants

Reactant 2

HCID 22140884Cyclopropanecarbothioamide

HCID 648982873-Chloro-3-(3-fluoro-4-methyl-phenyl)-2-oxo-propionic acid methyl ester

Product 1

HCID 668656622-Cyclopropyl-5-(3-fluoro-4-methyl-phenyl)-thiazole-4-carboxylic Acid Methyl Ester

Procedure

prepared by reaction of 3-chloro-3-(3-fluoro-4-methyl-phenyl)-2-oxo-propionic acid methyl ester with cyclopropanecarbothioic acid amide. LC-MS: tR=1.06 min; [M+H]+=292.1.

Sources & evidence

ORD record: ord-95f1975049f24ea68babea9efb7c942b
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288435B2

Reaction notes

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