Thiourea → methyl 2-amino-5-(2-fluorophenyl)-1,3-thiazole-4-carboxylate

HRID 2064727Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[F:12].[NH2:16][C:17]([NH2:19])=[S:18]>>[CH3:1][O:2][C:3]([C:4]1[N:16]=[C:17]([NH2:19])[S:18][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[F:12])=[O:15]

Participants

Reactant 2

HCID 2723790Thiourea

HCID 54289762HCID 54289762, compound

Product 1

HCID 2782987methyl 2-amino-5-(2-fluorophenyl)-1,3-thiazole-4-carboxylate

Procedure

prepared by reaction of 3-chloro-3-(2-fluoro-phenyl)-2-oxo-propionic acid methyl ester with thiourea. LC-MS: tR=0.76 min; [M+H]+=253.2.

Sources & evidence

ORD record: ord-b74a58989fea465ab98f6e8dafded3bb
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288435B2

Reaction notes

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