Thiourea → Methyl 2-amino-5-phenyl-1,3-thiazole-4-carboxylate

HRID 2064732Notes

Reaction equation

HRID 2064732 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH2:15][C:16]([NH2:18])=[S:17]>>[CH3:1][O:2][C:3]([C:4]1[N:15]=[C:16]([NH2:18])[S:17][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:14]

Participants

3

Reactant 2

HCID 2723790ThioureaHCID 11769817Methyl 3-chloro-2-oxo-3-phenylpropanoate

Product 1

HCID 664327Methyl 2-amino-5-phenyl-1,3-thiazole-4-carboxylate

Procedure

prepared by reaction of 3-chloro-2-oxo-3-phenyl-propionic acid methyl ester with thiourea. LC-MS: tR=0.77 min; [M+H]+=235.1.

Sources & evidence

ORD record
ord-2dbeb82616244c4196a9b8efc1c1e2ca
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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