反应详情

A solution of benzo[d]isothiazole-3-carboxylic acid amide (5.05 mmol) in MeOH (100 mL) is treated with an aqueous NaOH solution (10 M, 10.0 mL) and heated to reflux for 16 h. The mixture is cooled to RT, concentrated in vacuo, made acidic by addition of hydrochloric acid (pH<2) and kept for 2 h at 0° C. The obtained precipitate is filtered off and dried in vacuo to give the desired product which is used without further purification. LC-MS: tR=0.73 min; [M+H]+=180.0.

1. temperatureheated
2. temperatureto reflux for 16 h
3. concentrationconcentrated in vacuo
4. additionmade acidic by addition of hydrochloric acid (pH<2)
5. filtrationThe obtained precipitate is filtered off
6. customdried in vacuo