HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyl bromide → 3-Allyloxy-4-chloro-benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 4-chloro-3-hydroxybenzoate | HCID 58847555 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-Allyloxy-4-chloro-benzoic acid ethyl ester | HCID 66998786 | — |
Reaction Steps
K2CO3 (78.5 mmol) and 3-bromo-1-propen (52.3 mmol) are added to a solution of 4-chloro-3-hydroxy-benzoic acid ethyl ester (26.2 mmol) in acetone (50 mL). The mixture is heated to reflux for 16 h and cooled to RT. The solvents are removed in vacuo to give the desired product which is used without further purification. LC-MS: tR=1.05 min; [M+H]+=240.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288435B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-f721484761314cf0bd182e6316f9dab7 |
| Source note | uspto-grants-2012_10 |