反应详情

N-Bromosuccinimide (0.56 mmol) is added to a solution of pyrrolo[2,1-b]thiazole-7-carboxylic acid ethyl ester (0.56 mmol) in DCM (6.0 mL). After 30 min water (5.0 mL) is added, the layers are separated and the aqueous layer is extracted with DCM (5.0 mL). The combined organic layers are dried over Na SO and the solvents are removed in vacuo to give the desired product which is used without further purification. LC-MS: tR=1.02 min; [M+H]+=273.9.

1. customthe layers are separated
2. extractionthe aqueous layer is extracted with DCM (5.0 mL)
3. customThe combined organic layers are dried over Na SO
4. customthe solvents are removed in vacuo