HRID2064795

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78184

2,3-Dihydro-1,4-benzodioxin-5-carboxylic acid

C9H8O4

结构：CC(C)(C)OC(=O)N1[C@H](CN)C[C@@H]2C[C@@H]21

HCID58278675

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1[C@H](CNC(=O)c2cccc3c2OCCO3)C[C@@H]2C[C@@H]21

HCID67081183

未命名化合物

PROCEDURE

实验过程

prepared by reaction of (1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester with 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid. LC-MS (acidic): tR=0.97 min; [M+H]+=375.1. 1H-NMR (CDCl3): δ=0.61 (bs, 1H); 0.76-0.82 (m, 1H); 1.47-1.52 (m, 1H); 1.51 (s, 9H); 1.89 (bd, J=13.2 Hz, 1H); 2.42-2.47 (m, 1H); 3.34-3.74 (m, 3H); 4.30-4.35 (m, 1H); 4.32 (bs, 2H); 4.44 (bs, 2H); 6.91-7.05 (m, 2H); 7.67-7.73 (m, 1H); 8.43 (bs, NH).