HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoquinoline-1-carboxylic acid → (1S,3S,5S)-3-{[(Isoquinoline-1-carbonyl)-amino]-methyl}-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoquinoline-1-carboxylic acid | HCID 68092 | — |
| Reactant | (1S,3S,5S)-tert-Butyl 3-(aminomethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate | HCID 58278675 | — |
| Product | (1S,3S,5S)-3-{[(Isoquinoline-1-carbonyl)-amino]-methyl}-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester | HCID 67081402 | — |
Reaction Steps
prepared by reaction of (1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester with isoquinoline-1-carboxylic acid. LC-MS (acidic): tR=1.04 min; [M+H]+=368.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288435B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-0c13b3505de54a578ce2e0264c5c9d1c |
| Source note | uspto-grants-2012_10 |