1,2-Benzoxazole-3-carboxylic acid → HCID 67081436, compound

HRID 2064802Notes

Reaction equation

HRID 2064802 reaction equation
[C:1]([O:5][C:6]([N:8]1[C@H:13]([CH2:14][NH2:15])[CH2:12][C@H:11]2[C@@H:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[C:18]([C:25](O)=[O:26])=[N:17]1>>[C:1]([O:5][C:6]([N:8]1[C@H:13]([CH2:14][NH:15][C:25]([C:18]2[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:16][N:17]=2)=[O:26])[CH2:12][C@H:11]2[C@@H:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27354451,2-Benzoxazole-3-carboxylic acidHCID 58278675(1S,3S,5S)-tert-Butyl 3-(aminomethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

Product 1

HCID 67081436HCID 67081436, compound

Procedure

prepared by reaction of (1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester with benzo[d]isoxazole-3-carboxylic acid. LC-MS (acidic): tR=0.92 min; [M+H]+=358.2.

Sources & evidence

ORD record
ord-31d3ceb372c4456292fffe43ecf2a3b5
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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