2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid → HCID 86653642, compound

HRID 2064807Notes

Reaction equation

HRID 2064807 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][C@@H:3]([CH2:7][NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11])[NH:2]2.[CH3:15][C:16]1[S:17][C:18]([C:24]2[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=2)=[C:19]([C:21](O)=[O:22])[N:20]=1>>[F:11][C:10]([F:12])([F:13])[C:9]([NH:8][CH2:7][C@@H:3]1[CH2:4][C@H:5]2[C@H:1]([CH2:6]2)[N:2]1[C:21]([C:19]1[N:20]=[C:16]([CH3:15])[S:17][C:18]=1[C:24]1[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=1)=[O:22])=[O:14]

Participants

3

Reactant 2

HCID 532718162-Methyl-5-m-tolyl-thiazole-4-carboxylic acidHCID 86653639N-[(1S,3S,5S)-2-Azabicyclo[3.1.0]hex-3-ylmethyl]-2,2,2-trifluoroacetamide

Product 1

HCID 86653642HCID 86653642, compound

Procedure

prepared by reaction of N-[(1S,3S,5S)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-2,2,2-trifluoro-acetamide with 2-methyl-5-m-tolyl-thiazole-4-carboxylic acid. LC-MS (acidic): tR=0.99 min; [M+H]+=424.1.

Sources & evidence

ORD record
ord-16f2b045633b4f3e9a36e3e0c0eff352
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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