5-(3-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid → HCID 86653643, compound

HRID 2064808Notes

Reaction equation

HRID 2064808 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][C@@H:3]([CH2:7][NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11])[NH:2]2.[Cl:15][C:16]1[CH:17]=[C:18]([C:22]2[S:26][C:25]([CH3:27])=[N:24][C:23]=2[C:28](O)=[O:29])[CH:19]=[CH:20][CH:21]=1>>[Cl:15][C:16]1[CH:17]=[C:18]([C:22]2[S:26][C:25]([CH3:27])=[N:24][C:23]=2[C:28]([N:2]2[C@H:3]([CH2:7][NH:8][C:9](=[O:14])[C:10]([F:12])([F:13])[F:11])[CH2:4][C@H:5]3[C@@H:1]2[CH2:6]3)=[O:29])[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 532711925-(3-Chloro-phenyl)-2-methyl-thiazole-4-carboxylic acidHCID 86653639N-[(1S,3S,5S)-2-Azabicyclo[3.1.0]hex-3-ylmethyl]-2,2,2-trifluoroacetamide

Product 1

HCID 86653643HCID 86653643, compound

Procedure

prepared by reaction of N-[(1S,3S,5S)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-2,2,2-trifluoro-acetamide with 5-(3-chloro-phenyl)-2-methyl-thiazole-4-carboxylic acid. LC-MS (acidic): tR=0.99 min; [M+H]+=444.1.

Sources & evidence

ORD record
ord-d9eda4f48dce42f6b0834a81b8207843
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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