HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-(3-fluorophenyl)-1,3-thiazole-4-carboxylic acid → 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-(3-fluorophenyl)-1,3-thiazole-4-carboxylic acid | HCID 57437179 | — |
| Reactant | 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid [(1S,3S,5S)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide | HCID 67081414 | — |
| Product | 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide | HCID 86653653 | — |
Reaction Steps
prepared by reaction of 2,3-dihydro-benzo[1,4]dioxine-5-carboxylic acid [(1S,3S,5S)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide with 2-amino-5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid. LC-MS (basic): tR=1.28 min; [M+H]+=495.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288435B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-77d73ba7eab64497ac763b0b883831d0 |
| Source note | uspto-grants-2012_10 |