2-Amino-5-(3-fluorophenyl)-1,3-thiazole-4-carboxylic acid → HCID 86653656, compound

HRID 2064846Notes

Reaction equation

HRID 2064846 reaction equation
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][C@@H:3]([CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:17])=[N:13][O:14][C:15]=1[CH3:16])=[O:10])[NH:2]2.[NH2:18][C:19]1[S:20][C:21]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=2)=[C:22]([C:24](O)=[O:25])[N:23]=1>>[NH2:18][C:19]1[S:20][C:21]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=2)=[C:22]([C:24]([N:2]2[C@H:3]([CH2:7][NH:8][C:9]([C:11]3[C:12]([CH3:17])=[N:13][O:14][C:15]=3[CH3:16])=[O:10])[CH2:4][C@H:5]3[C@@H:1]2[CH2:6]3)=[O:25])[N:23]=1

Participants

3

Reactant 2

HCID 574371792-Amino-5-(3-fluorophenyl)-1,3-thiazole-4-carboxylic acidHCID 67081314HCID 67081314, compound

Product 1

HCID 86653656HCID 86653656, compound

Procedure

prepared by reaction of 3,5-dimethyl-isoxazole-4-carboxylic acid [(1S,3S,5S)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide with 2-amino-5-(3-fluoro-phenyl)-thiazole-4-carboxylic acid. LC-MS (basic): tR=1.23 min; [M+H]+=456.1.

Sources & evidence

ORD record
ord-957c643057324762be17252ee5a09bc2
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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