1,2-Benzoxazole-3-carboxylic acid → HCID 67081326, compound

HRID 2064856Notes

Reaction equation

HRID 2064856 reaction equation
[NH2:1][CH2:2][C@@H:3]1[CH2:8][C@H:7]2[C@H:5]([CH2:6]2)[N:4]1[C:9]([C:11]1[N:12]=[C:13]([CH3:23])[S:14][C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=1)=[O:10].[O:24]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[C:26]([C:33](O)=[O:34])=[N:25]1>>[F:22][C:18]1[CH:17]=[C:16]([C:15]2[S:14][C:13]([CH3:23])=[N:12][C:11]=2[C:9]([N:4]2[C@H:3]([CH2:2][NH:1][C:33]([C:26]3[C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[O:24][N:25]=3)=[O:34])[CH2:8][C@H:7]3[C@@H:5]2[CH2:6]3)=[O:10])[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 27354451,2-Benzoxazole-3-carboxylic acidHCID 67081101[(1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl]-[5-(3-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone

Product 1

HCID 67081326HCID 67081326, compound

Procedure

prepared by reaction of [(1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl]-[5-(3-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone with benzo[d]isoxazole-3-carboxylic acid. LC-MS (basic): tR=0.90 min; [M+H]+=477.1.

Sources & evidence

ORD record
ord-5214971d0f2d4c5f94f975f7471afb9b
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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