HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,2-Difluoro-1,3-dioxaindane-4-carboxylic acid → 2,2-difluoro-benzo[1,3]dioxole-4-carboxylic acid {(1S,3S,5S)-2-[5-(3-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,2-Difluoro-1,3-dioxaindane-4-carboxylic acid | HCID 2774067 | — |
| Edukt | [(1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl]-[5-(3-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone | HCID 67081101 | — |
| Produkt | 2,2-difluoro-benzo[1,3]dioxole-4-carboxylic acid {(1S,3S,5S)-2-[5-(3-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide | HCID 67081319 | — |
Reaktionsschritte
prepared by reaction of [(1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl]-[5-(3-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone with 2,2-difluoro-benzo[1,3]dioxole-4-carboxylic acid. LC-MS (basic): tR=0.94 min; [M+H]+=516.1.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08288435B2 |
| Quelldatensatz | uspto-grants-2012_10 |
| ORD ID | ord-9ad6b0a8b9c1428b9138950e28820cfd |
| Quellennotiz | uspto-grants-2012_10 |