HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylindole-3-carboxylic acid → 1-methyl-1H-indole-3-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylindole-3-carboxylic acid | HCID 854040 | — |
| Reactant | [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone | HCID 86653658 | — |
| Product | 1-methyl-1H-indole-3-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide | HCID 86653661 | — |
Reaction Steps
prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 1-methyl-1H-indole-3-carboxylic acid. LC-MS (basic): tR=0.81 min; [M+H]+=489.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288435B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-71ffe4b411674804b6f580d0ecc28d0a |
| Source note | uspto-grants-2012_10 |