Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methyl-5-(trifluoromethyl)-1,2-oxazole-4-carboxylic acid → 3-methyl-5-trifluoromethyl-isoxazole-4-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methyl-5-(trifluoromethyl)-1,2-oxazole-4-carboxylic acid | HCID 2775645 | — |
| 반응물 | [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone | HCID 86653658 | — |
| 생성물 | 3-methyl-5-trifluoromethyl-isoxazole-4-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide | HCID 86653672 | — |
반응 단계
prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 3-methyl-5-trifluoromethyl-isoxazole-4-carboxylic acid. LC-MS (basic): tR=0.85 min; [M+H]+=510.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08288435B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-aaabb6576e624366b565e111966b39f4 |
| 출처 메모 | uspto-grants-2012_10 |