1-Methyl-5-(trifluoromethyl)pyrazole-4-carboxylic Acid → HCID 86653680, compound

HRID 2064889Notes

Reaction equation

HRID 2064889 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH2:16])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1.[CH3:24][N:25]1[C:29]([C:30]([F:33])([F:32])[F:31])=[C:28]([C:34](O)=[O:35])[CH:27]=[N:26]1>>[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:34]([C:28]3[CH:27]=[N:26][N:25]([CH3:24])[C:29]=3[C:30]([F:33])([F:31])[F:32])=[O:35])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1

Participants

3

Reactant 2

HCID 28077711-Methyl-5-(trifluoromethyl)pyrazole-4-carboxylic AcidHCID 86653658[2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone

Product 1

HCID 86653680HCID 86653680, compound

Procedure

prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 1-methyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid. LC-MS (basic): tR=0.79 min; [M+H]+=509.2.

Sources & evidence

ORD record
ord-ed4573ea3da9452aa4c9e1712c01b394
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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