2,3-Dihydro-1-benzofuran-4-carboxylic acid → HCID 86653685, compound

HRID 2064894Notes

Reaction equation

HRID 2064894 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH2:16])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1.[O:24]1[C:28]2=[CH:29][CH:30]=[CH:31][C:32]([C:33](O)=[O:34])=[C:27]2[CH2:26][CH2:25]1>>[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:33]([C:32]3[CH:31]=[CH:30][CH:29]=[C:28]4[O:24][CH2:25][CH2:26][C:27]=34)=[O:34])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1

Participants

3

Reactant 2

HCID 187874442,3-Dihydro-1-benzofuran-4-carboxylic acidHCID 86653658[2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone

Product 1

HCID 86653685HCID 86653685, compound

Procedure

prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 2,3-dihydro-benzo furan-4-carboxylic acid. LC-MS (basic): tR=0.81 min; [M+H]+=479.2.

Sources & evidence

ORD record
ord-ca10b8d2446b410983f4dea621ce0b24
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

Loading…