1,3-dimethyl-1H-pyrazole-4-carboxylic acid → HCID 86653686, compound

HRID 2064895Notes

Reaction equation

HRID 2064895 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH2:16])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1.[CH3:24][N:25]1[CH:29]=[C:28]([C:30](O)=[O:31])[C:27]([CH3:33])=[N:26]1>>[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:30]([C:28]3[C:27]([CH3:33])=[N:26][N:25]([CH3:24])[CH:29]=3)=[O:31])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1

Participants

3

Reactant 2

HCID 12733041,3-dimethyl-1H-pyrazole-4-carboxylic acidHCID 86653658[2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone

Product 1

HCID 86653686HCID 86653686, compound

Procedure

prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 1,3-dimethyl-1H-pyrazole-4-carboxylic acid. LC-MS (basic): tR=0.71 min; [M+H]+=455.2.

Sources & evidence

ORD record
ord-c5b5f48e850d4a0ea82e02013e228511
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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