5-Ethyl-3-methyl-isoxazole-4-carboxylic acid → HCID 86653687, compound

HRID 2064896Notes

Reaction equation

HRID 2064896 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH2:16])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1.[CH2:24]([C:26]1[O:30][N:29]=[C:28]([CH3:31])[C:27]=1[C:32](O)=[O:33])[CH3:25]>>[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:32]([C:27]3[C:28]([CH3:31])=[N:29][O:30][C:26]=3[CH2:24][CH3:25])=[O:33])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1

Participants

3

Reactant 2

HCID 39188995-Ethyl-3-methyl-isoxazole-4-carboxylic acidHCID 86653658[2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone

Product 1

HCID 86653687HCID 86653687, compound

Procedure

prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 5-ethyl-3-methyl-isoxazole-4-carboxylic acid. LC-MS (basic): tR=0.80 min; [M+H]+=470.1.

Sources & evidence

ORD record
ord-39128adca8324c42ab303753c6d00384
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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