HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2064906Generated: October 25, 2026
Vorinostat → N-hydroxy-N'-phenyloctanediamide vorinostat
https://huagongshe.com/reaction/2064906
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Vorinostat | HCID 5311 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | N-hydroxy-N'-phenyloctanediamide vorinostat | HCID 86620476 | — |
Reaction Steps
The seed slurry is prepared by combining vorinostat—fine dry cake (97.8-116.3 g, 0.37-0.44 mol) and 50:50 (v/v) ethanol/water solution (1.0-1.2 L). Under a minimum of 15 psig pressure, the seed slurry is heated to 62-66° C., aged for about 0.5 hours and then cooled to 60-64° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08288440B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-8abf0c6c44de43bab2ee6b1ad8691665 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
