Nitrogen → 1-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a mixture of 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-3-nitro-1H-pyrazole (173 mg, 0.62 mmol), iron powder (105 mg, 1.86 mmol) and NH4Cl (167 mg, 3.10 mmol) in a mixture of EtOH (4.0 mL) and water (2.0 mL) was stirred at 75° C. for 40 min. The reaction mixture was filtered while hot and concentrated under reduced pressure. CH2Cl2 (15 mL) was added followed by water (15 mL). The aq. layer was extracted with CH2Cl2 (2×15 mL) and the combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.62 min; [M+H]+=250.34.

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