Nitrogen → HCID 178455423, compound

Participants

Reaction Steps

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 5-[3-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-oxazole-4-carboxylic acid methyl ester (673 mg, 1.94 mmol) in 1:1 THF:H2O (6.4 mL) was treated with lithium hydroxide monohydrate (115 mg, 2.71 mmol). The resulting mixture was stirred for 2.5 h. EA (20 mL) was added and the organic phase was washed with 1N HCl (10 mL), dried over MgSO4, filtered, and the solvent removed under reduced pressure to give the title compound as a white solid. LC-MS-conditions 02: tR=1.07 min, [M+H]+=334.13.

Provenance & Evidence