Nitrogen → HCID 66929171, compound

Participants

Reaction Steps

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 2-(tert-butoxycarbonylamino-methyl)-5-phenyl-oxazole-4-carboxylic acid methyl ester (200 mg, 0.60 mmol) in dioxane (2.0 mL) was treated with 1N LiOH (2.0 mL). The resulting mixture was stirred for 1 h. EA (10 mL) was added and the organic phase was washed with 1N HCl (3 mL), dried over MgSO4, filtered, and the solvent removed under reduced pressure to give the title compound as a white solid. LC-MS-conditions 02: tR=0.89 min, [M+H]+=319.17.

Provenance & Evidence