Isobutyric Acid → 2-Isopropyl-5-phenyl-oxazole-4-carboxylic acid

HRID 2065094Notes

Reaction equation

[CH:1]1[CH:6]=[CH:5][C:4]([CH:7]([OH:13])[CH:8]([NH2:12])[C:9]([OH:11])=[O:10])=[CH:3][CH:2]=1.[C:14](O)(=O)[CH:15]([CH3:17])[CH3:16]>>[CH:15]([C:17]1[O:13][C:7]([C:4]2[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=2)=[C:8]([C:9]([OH:11])=[O:10])[N:12]=1)([CH3:16])[CH3:14]

Participants

Reactant 2

HCID 6590Isobutyric Acid

HCID 94134DL-Phenylserine

Product 1

HCID 669291502-Isopropyl-5-phenyl-oxazole-4-carboxylic acid

Procedure

Prepared starting from DL-3-phenylserine hydrate following sequentially general procedures Y, Z with isobutyric acid, Z1 and Z2. LC-MS-conditions 02: tR=0.90 min; [M+H]+=232.51.

Workup

customPrepared

Sources & evidence

ORD record: ord-dce5f8b85c4344768b4b8970da8e4a9f
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288419B2

Reaction notes

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