Pentanoic Acid → 2-Butyl-5-phenyl-oxazole-4-carboxylic acid

HRID 2065095Notes

Reaction equation

[CH:1]1[CH:6]=[CH:5][C:4]([CH:7]([OH:13])[CH:8]([NH2:12])[C:9]([OH:11])=[O:10])=[CH:3][CH:2]=1.[C:14](O)(=O)[CH2:15][CH2:16][CH2:17][CH3:18]>>[CH2:15]([C:14]1[O:13][C:7]([C:4]2[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=2)=[C:8]([C:9]([OH:11])=[O:10])[N:12]=1)[CH2:16][CH2:17][CH3:18]

Participants

Reactant 2

HCID 7991Pentanoic Acid

HCID 94134DL-Phenylserine

Product 1

HCID 669291182-Butyl-5-phenyl-oxazole-4-carboxylic acid

Procedure

Prepared starting from DL-3-phenylserine hydrate following sequentially general procedures Y, Z with pentanoic acid, Z1 and Z2. LC-MS-conditions 02: tR=0.95 min; [M+H]+=246.45.

Workup

customPrepared

Sources & evidence

ORD record: ord-7d51486a95fe4f119d4924ec414adcb3
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288419B2

Reaction notes

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