[1-(5-Formyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester → [1-(5-Cyclopropanecarbonyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester

HRID 2065100Notes

Reaction equation

HRID 2065100 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][O:5][C:6](=[O:21])[NH:7][C:8]1[CH:9]=[N:10][N:11]([CH2:13][C:14]2[O:15][C:16]([CH:19]=[O:20])=[CH:17][CH:18]=2)[CH:12]=1.[CH:26]1([Mg]Br)[CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[CH2:4][O:5][C:6](=[O:21])[NH:7][C:8]1[CH:9]=[N:10][N:11]([CH2:13][C:14]2[O:15][C:16]([C:19]([CH:26]3[CH2:28][CH2:27]3)=[O:20])=[CH:17][CH:18]=2)[CH:12]=1

Participants

3

Reactant 2

HCID 86650886[1-(5-Formyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl esterHCID 178418630HCID 178418630, compound

Product 1

HCID 42646794[1-(5-Cyclopropanecarbonyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester

Procedure

Following general procedures G and H, starting from [1-(5-formyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-carbamic acid 2-chloro-benzyl ester and cyclopropylmagnesium bromide.

Sources & evidence

ORD record
ord-d4faf739b7c34ddcb6c8be9d041c514c
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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