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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2065105Generated: October 25, 2026

4-(Trifluoromethyl)cinnamic acid → (E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-acrylamide

https://huagongshe.com/reaction/2065105

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)cinnamic acidHCID 688070—
Reactant1-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamineHCID 66928781—
Product(E)-N-[1-(5-Acetyl-furan-2-ylmethyl)-1H-pyrazol-3-yl]-3-(4-trifluoromethyl-phenyl)-acrylamideHCID 42644162—

Reaction Steps

Following general procedure B followed by either C or D, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(4-trifluoromethyl-phenyl)-acrylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08288419B2
Source datasetuspto-grants-2012_10
ORD IDord-88c7424150c84ba7a83cfcca839e04e3
Source noteuspto-grants-2012_10