2-Chloro-3,6-difluorocinnamic acid → HCID 42644400, compound

HRID 2065111Notes

Reaction equation

HRID 2065111 reaction equation
[CH3:1][C:2]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH:17]=[CH:16][C:15]([NH2:18])=[N:14]3)=[CH:9][CH:8]=2)[O:6]CCO1.[Cl:19][C:20]1[C:25]([F:26])=[CH:24][CH:23]=[C:22]([F:27])[C:21]=1/[CH:28]=[CH:29]/[C:30](O)=[O:31]>>[C:2]([C:7]1[O:11][C:10]([CH2:12][N:13]2[CH:17]=[CH:16][C:15]([NH:18][C:30](=[O:31])/[CH:29]=[CH:28]/[C:21]3[C:22]([F:27])=[CH:23][CH:24]=[C:25]([F:26])[C:20]=3[Cl:19])=[N:14]2)=[CH:9][CH:8]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 57083902-Chloro-3,6-difluorocinnamic acidHCID 669287811-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine

Product 1

HCID 42644400HCID 42644400, compound

Procedure

Following general procedure B followed by either C or D, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(2-chloro-3,6-difluoro-phenyl)-acrylic acid.

Sources & evidence

ORD record
ord-48b7339c42584cb8a5dfb3ea2cc60514
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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