2-Fluoro-3-(trifluoromethyl)cinnamic acid → HCID 42644636, compound

HRID 2065115Notes

Reaction equation

HRID 2065115 reaction equation
[CH3:1][C:2]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[CH:17]=[CH:16][C:15]([NH2:18])=[N:14]3)=[CH:9][CH:8]=2)[O:6]CCO1.[F:19][C:20]1[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:23]=[CH:22][C:21]=1/[CH:30]=[CH:31]/[C:32](O)=[O:33]>>[C:2]([C:7]1[O:11][C:10]([CH2:12][N:13]2[CH:17]=[CH:16][C:15]([NH:18][C:32](=[O:33])/[CH:31]=[CH:30]/[C:21]3[CH:22]=[CH:23][CH:24]=[C:25]([C:26]([F:28])([F:27])[F:29])[C:20]=3[F:19])=[N:14]2)=[CH:9][CH:8]=1)(=[O:6])[CH3:1]

Participants

3

Reactant 2

HCID 57028922-Fluoro-3-(trifluoromethyl)cinnamic acidHCID 669287811-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine

Product 1

HCID 42644636HCID 42644636, compound

Procedure

Following general procedure B followed by either C or D, starting from 1-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(2-fluoro-3-trifluoromethyl-phenyl)-acrylic acid.

Sources & evidence

ORD record
ord-f0fd81bd7bc94099b36d50a612e585a7
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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