5-Phenyl-1,3-oxazole-4-carboxylic acid → 5-Phenyl-oxazole-4-carboxylic acid [1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-amide

HRID 2065166Notes

Reaction equation

HRID 2065166 reaction equation
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12]2)[O:6]CCO1.[C:17]1([C:23]2[O:27][CH:26]=[N:25][C:24]=2[C:28](O)=[O:29])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[O:6]=[C:2]([CH3:1])[CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:15]=[C:14]([NH:16][C:28]([C:24]2[N:25]=[CH:26][O:27][C:23]=2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:29])[CH:13]=[N:12]1

Participants

3

Reactant 2

HCID 27762995-Phenyl-1,3-oxazole-4-carboxylic acidHCID 669287261-[4-(2-Methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine

Product 1

HCID 669289795-Phenyl-oxazole-4-carboxylic acid [1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-amide

Procedure

Following general procedure B followed by either C or D, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine and 5-phenyl-oxazole-4-carboxylic acid.

Sources & evidence

ORD record
ord-692e83c0518047b2807613d174620543
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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