5-(4-Methoxyphenyl)-1,3-oxazole-4-carboxylic acid → 5-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-amide

HRID 2065172Notes

Reaction equation

HRID 2065172 reaction equation
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12]2)[O:6]CCO1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[O:29][CH:28]=[N:27][C:26]=2[C:30](O)=[O:31])=[CH:21][CH:20]=1>>[O:6]=[C:2]([CH3:1])[CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:15]=[C:14]([NH:16][C:30]([C:26]2[N:27]=[CH:28][O:29][C:25]=2[C:22]2[CH:23]=[CH:24][C:19]([O:18][CH3:17])=[CH:20][CH:21]=2)=[O:31])[CH:13]=[N:12]1

Participants

3

Reactant 2

HCID 27797825-(4-Methoxyphenyl)-1,3-oxazole-4-carboxylic acidHCID 669287261-[4-(2-Methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine

Product 1

HCID 669294825-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid [1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-amide

Procedure

Following general procedure B followed by either C or D, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine and 5-(4-methoxy-phenyl)-oxazole-4-carboxylic acid.

Sources & evidence

ORD record
ord-627a536ebc2644eda0acfa360f7573d6
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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