2-Fluoro-3-(trifluoromethyl)cinnamic acid → HCID 66928960, compound

HRID 2065187Notes

Reaction equation

HRID 2065187 reaction equation
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]2)[O:6]CCO1.[F:17][C:18]1[C:23]([C:24]([F:27])([F:26])[F:25])=[CH:22][CH:21]=[CH:20][C:19]=1/[CH:28]=[CH:29]/[C:30](O)=[O:31]>>[F:17][C:18]1[C:23]([C:24]([F:26])([F:27])[F:25])=[CH:22][CH:21]=[CH:20][C:19]=1/[CH:28]=[CH:29]/[C:30]([NH:16][C:13]1[CH:14]=[CH:15][N:11]([CH2:10][CH2:9][CH2:8][CH2:7][C:2](=[O:6])[CH3:1])[N:12]=1)=[O:31]

Participants

3

Reactant 2

HCID 57028922-Fluoro-3-(trifluoromethyl)cinnamic acidHCID 669284811-[4-(2-Methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-3-ylamine

Product 1

HCID 66928960HCID 66928960, compound

Procedure

Following general procedure B followed by either C or D, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-3-ylamine and (E)-3-(2-fluoro-3-trifluoromethyl-phenyl)-acrylic acid.

Sources & evidence

ORD record
ord-45929c681a3b4d12a88861701928f65d
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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