2-Propenoic acid, 3-(3-chlorophenyl)- → (E)-3-(3-Chloro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-acrylamide

HRID 2065192Notes

Reaction equation

HRID 2065192 reaction equation
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]2)[O:6]CCO1.[Cl:17][C:18]1[CH:19]=[C:20](/[CH:24]=[CH:25]/[C:26](O)=[O:27])[CH:21]=[CH:22][CH:23]=1>>[Cl:17][C:18]1[CH:19]=[C:20](/[CH:24]=[CH:25]/[C:26]([NH:16][C:13]2[CH:14]=[CH:15][N:11]([CH2:10][CH2:9][CH2:8][CH2:7][C:2](=[O:6])[CH3:1])[N:12]=2)=[O:27])[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 7352502-Propenoic acid, 3-(3-chlorophenyl)-HCID 669284811-[4-(2-Methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-3-ylamine

Product 1

HCID 66929387(E)-3-(3-Chloro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-3-yl]-acrylamide

Procedure

Following general procedure B followed by either C or D, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-3-ylamine and (E)-3-(3-chloro-phenyl)-acrylic acid.

Sources & evidence

ORD record
ord-bc9620e396164dadad5644b2b562e65e
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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