1-(5,5-Difluoro-hexyl)-1H-pyrazol-4-ylamine → 2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [1-(5,5-difluoro-hexyl)-1H-pyrazol-4-yl]-amide

HRID 2065200Notes

Reaction equation

HRID 2065200 reaction equation
[F:1][C:2]([F:14])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[C:10]([NH2:12])[CH:9]=[N:8]1.[CH3:15][C:16]1[O:17][C:18]([C:24]2[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=2)=[C:19]([C:21](O)=[O:22])[N:20]=1>>[F:14][C:2]([F:1])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[C:10]([NH:12][C:21]([C:19]2[N:20]=[C:16]([CH3:15])[O:17][C:18]=2[C:24]2[CH:25]=[C:26]([CH3:30])[CH:27]=[CH:28][CH:29]=2)=[O:22])[CH:9]=[N:8]1

Participants

3

Reactant 2

HCID 669291721-(5,5-Difluoro-hexyl)-1H-pyrazol-4-ylamineHCID 669292052-Methyl-5-(m-tolyl)oxazole-4-carboxylic acid

Product 1

HCID 669286272-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [1-(5,5-difluoro-hexyl)-1H-pyrazol-4-yl]-amide

Procedure

Following general procedure B, starting from 1-(5,5-difluoro-hexyl)-1H-pyrazol-4-ylamine and 2-methyl-5-m-tolyl-oxazole-4-carboxylic acid. LC-MS-conditions 05b: tR=1.18 min; [M+H]+=403.28.

Sources & evidence

ORD record
ord-cd4f9e5b050a4ba3a70c96eb46d01d19
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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