4-(Trifluoromethyl)cinnamic acid → HCID 66929213, compound

HRID 2065207Notes

Reaction equation

HRID 2065207 reaction equation
[F:1][C:2]([F:14])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH2:12])=[N:8]1.[F:15][C:16]([F:29])([F:28])[C:17]1[CH:22]=[CH:21][C:20](/[CH:23]=[CH:24]/[C:25](O)=[O:26])=[CH:19][CH:18]=1>>[F:14][C:2]([F:1])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH:12][C:25](=[O:26])/[CH:24]=[CH:23]/[C:20]2[CH:19]=[CH:18][C:17]([C:16]([F:28])([F:29])[F:15])=[CH:22][CH:21]=2)=[N:8]1

Participants

3

Reactant 2

HCID 6880704-(Trifluoromethyl)cinnamic acidHCID 669283041-(5,5-Difluoro-hexyl)-1H-pyrazol-3-ylamine

Product 1

HCID 66929213HCID 66929213, compound

Procedure

Following general procedure B, starting from 1-(5,5-difluoro-hexyl)-1H-pyrazol-3-ylamine and (E)-3-(4-trifluoromethyl-phenyl)-acrylic acid. LC-MS-conditions 05b: tR=1.16 min; [M+H]+=402.11.

Sources & evidence

ORD record
ord-c6b7186cab104122aac2ca77161fba1d
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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