4-Methylcinnamic Acid → (E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-p-tolyl-acrylamide

HRID 2065209Notes

Reaction equation

HRID 2065209 reaction equation
[F:1][C:2]([F:14])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH2:12])=[N:8]1.[C:15]1([CH3:26])[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23](O)=[O:24])=[CH:17][CH:16]=1>>[F:14][C:2]([F:1])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH:12][C:23](=[O:24])/[CH:22]=[CH:21]/[C:18]2[CH:19]=[CH:20][C:15]([CH3:26])=[CH:16][CH:17]=2)=[N:8]1

Participants

3

Reactant 2

HCID 7317674-Methylcinnamic AcidHCID 669283041-(5,5-Difluoro-hexyl)-1H-pyrazol-3-ylamine

Product 1

HCID 66929175(E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-p-tolyl-acrylamide

Procedure

Following general procedure B, starting from 1-(5,5-difluoro-hexyl)-1H-pyrazol-3-ylamine and (E)-3-p-tolyl-acrylic acid. LC-MS-conditions 05b: tR=1.12 min; [M+H]+=348.31.

Sources & evidence

ORD record
ord-12210c9599ca4660bfc90ae8291333c5
Source dataset
uspto-grants-2012_10
Patent number
US08288419B2

Reaction notes

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